Mathematical Modeling of Brain Cancer to Identify Promising Combination Treatments

For aggressive brain cancers such as glioblastoma multiforme (gbm), much of the discussion on this web site and others are on clinical trials for new agents. This is largely because the existing arsenal of treatments is so weak. The clinical trials take drugs that seem promising and test them for safety and efficacy. The trials have prevented widespread use of agents that were dangerous, and have led to some improvements in brain tumor treatments. Life has been marginally extended. Newer treatments generally have fewer side effects than older ones for a similar level of effectiveness.